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Alteration of antioxidant enzymes and oxidative stress in elderly patient.

Seema L. Jawalekar1, Anil K. Bhutey2, Aarti Karnik3, Vasant T. Surve4.

Cited by (1)

Abstract
Reactive oxygen spaces are common by-products of many oxidative biochemical and physiological processes. Therefore the present study was carried out to evaluate the total antioxidant capacity, lipid peroxidation and status of superoxide dismutase in elderly patients with hypertension, Diabetes with hypertension and cardiovascular diseases. Total 85 patients of both sexes were included in the study and further classified into 3 groups as hypertensive, Diabetes with hypertension and cerebrovascular disease/stroke. The 26 healthy subjects who were not on any kind of prescribed medication or dietary restrictions were included in the control group. Malondialdehyde is estimated as a marker of lipid peroxidation, levels were significantly increased in all groups than controls (p<0.001). Superoxide dismutase and glutathione reductase activities was significantly lower in all groups than control (p<0.001), Glutathione peroxidase levels were decreased in all groups except hypertension (p<0.001), nitric oxide level were decreased in all the groups except cerebrovascular disease / stroke when compared to the control. Significantly lower level of total antioxidant capacity and prominent scavenger of superoxide anion radicals suggests that failure of antioxidant defense mechanism against oxidative stress may be an important factor in the pathogenesis of cardiovascular diseases.

Key words: Lipid peroxidation, Glutathione peroxidase, Malondialdehyde, Total antioxidant capacity, Nitric oxide.


 
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How to Cite this Article
Pubmed Style

Seema L. Jawalekar, Anil K. Bhutey, Aarti Karnik, Vasant T. Surve. Alteration of antioxidant enzymes and oxidative stress in elderly patient.. A J Physiol Biochem Pharmacol. 2013; 2(1): 37-43. doi:10.5455/jib.20130129093838


Web Style

Seema L. Jawalekar, Anil K. Bhutey, Aarti Karnik, Vasant T. Surve. Alteration of antioxidant enzymes and oxidative stress in elderly patient.. http://www.ajpbp.com/?mno=30388 [Access: December 16, 2018]. doi:10.5455/jib.20130129093838


AMA (American Medical Association) Style

Seema L. Jawalekar, Anil K. Bhutey, Aarti Karnik, Vasant T. Surve. Alteration of antioxidant enzymes and oxidative stress in elderly patient.. A J Physiol Biochem Pharmacol. 2013; 2(1): 37-43. doi:10.5455/jib.20130129093838



Vancouver/ICMJE Style

Seema L. Jawalekar, Anil K. Bhutey, Aarti Karnik, Vasant T. Surve. Alteration of antioxidant enzymes and oxidative stress in elderly patient.. A J Physiol Biochem Pharmacol. (2013), [cited December 16, 2018]; 2(1): 37-43. doi:10.5455/jib.20130129093838



Harvard Style

Seema L. Jawalekar, Anil K. Bhutey, Aarti Karnik, Vasant T. Surve (2013) Alteration of antioxidant enzymes and oxidative stress in elderly patient.. A J Physiol Biochem Pharmacol, 2 (1), 37-43. doi:10.5455/jib.20130129093838



Turabian Style

Seema L. Jawalekar, Anil K. Bhutey, Aarti Karnik, Vasant T. Surve. 2013. Alteration of antioxidant enzymes and oxidative stress in elderly patient.. American Journal of Physiology, Biochemistry and Pharmacology, 2 (1), 37-43. doi:10.5455/jib.20130129093838



Chicago Style

Seema L. Jawalekar, Anil K. Bhutey, Aarti Karnik, Vasant T. Surve. "Alteration of antioxidant enzymes and oxidative stress in elderly patient.." American Journal of Physiology, Biochemistry and Pharmacology 2 (2013), 37-43. doi:10.5455/jib.20130129093838



MLA (The Modern Language Association) Style

Seema L. Jawalekar, Anil K. Bhutey, Aarti Karnik, Vasant T. Surve. "Alteration of antioxidant enzymes and oxidative stress in elderly patient.." American Journal of Physiology, Biochemistry and Pharmacology 2.1 (2013), 37-43. Print. doi:10.5455/jib.20130129093838



APA (American Psychological Association) Style

Seema L. Jawalekar, Anil K. Bhutey, Aarti Karnik, Vasant T. Surve (2013) Alteration of antioxidant enzymes and oxidative stress in elderly patient.. American Journal of Physiology, Biochemistry and Pharmacology, 2 (1), 37-43. doi:10.5455/jib.20130129093838





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