E-ISSN 2578-7322
 

Original Research 


Crude ethanolic extract and fractions of buchholzia coriacea modifies salivary secretion and electrolyte compositions in rat

Olugbenga Adeola Odukanmi, Adeola Temitope Salami, Muideen Olayemi Isa, Samuel Babafemi Olaleye.

Abstract
Background: Extract of Buchholzia coriacea (BC) has been reported for its potent antimalarial effect. Unlike certain established antimalarial drugs reported for their roles in modifying saliva flow and components, BC effect on saliva is unknown. The effect of BC on saliva flow and its components was investigated.
Materials and Methods: Thirty Male Wistar rats 150.7 ± 13.3 g were used for the study. They were grouped into six (n=5) and treated with the various component of BC extract for 2 weeks. Group 1 (control) received distilled water, groups 2-6 received 200 mg/kg of the oily portion of the extract, 100 mg/kg, 200 mg/kg of the crude extract, 200 mg/kg absolute ethanol and 200 mg/kg aqueous ethanol fractions of BC respectively. Body weight, salivary flow rate, electrolyte compositions and morphological changes were determined using standard methods. Values were expressed as Mean ± standard error of mean, compared, analysed and considered significant at p<0.05
Results: The ethanol fraction of BC reduced significantly the salivary flow rate (0.03 ± 0.00 mL/min) compared with control (0.05 ± 0.00 mL/min). B.coriacea oil (44.24 ± 1.18 mmol/L) significantly reduce Na+ concentration compared to control (52.02 ± 2.52 mmol/L), absolute ethanol fraction (54.00 ± 1.59 mmol/L) and aqueous ethanol fractions (54.66 ± 1.66 mmol/L) respectively. The 200 mg/kg aqueous ethanol fraction of BC significantly increase HCO3- and K+ concentration compared to control. There was slight distortion on salivary gland of the BC treated groups compared to control.
Conclusion: This study suggests that BC modulates salivary flow rate and electrolytes composition in rats.

Key words: Buchholzia coriacea; electrolytes; histology; rats; salivary flow


 
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Pubmed Style

Odukanmi OA, Salami AT, Isa MO, Olaleye SB, . Crude ethanolic extract and fractions of buchholzia coriacea modifies salivary secretion and electrolyte compositions in rat. A J Physiol Biochem Pharmacol. 2019; 9(3): 45-51. doi:10.5455/ajpbp.20190411102349


Web Style

Odukanmi OA, Salami AT, Isa MO, Olaleye SB, . Crude ethanolic extract and fractions of buchholzia coriacea modifies salivary secretion and electrolyte compositions in rat. http://www.ajpbp.com/?mno=302644218 [Access: December 11, 2019]. doi:10.5455/ajpbp.20190411102349


AMA (American Medical Association) Style

Odukanmi OA, Salami AT, Isa MO, Olaleye SB, . Crude ethanolic extract and fractions of buchholzia coriacea modifies salivary secretion and electrolyte compositions in rat. A J Physiol Biochem Pharmacol. 2019; 9(3): 45-51. doi:10.5455/ajpbp.20190411102349



Vancouver/ICMJE Style

Odukanmi OA, Salami AT, Isa MO, Olaleye SB, . Crude ethanolic extract and fractions of buchholzia coriacea modifies salivary secretion and electrolyte compositions in rat. A J Physiol Biochem Pharmacol. (2019), [cited December 11, 2019]; 9(3): 45-51. doi:10.5455/ajpbp.20190411102349



Harvard Style

Odukanmi, O. A., Salami, A. T., Isa, M. O., Olaleye, S. B. & (2019) Crude ethanolic extract and fractions of buchholzia coriacea modifies salivary secretion and electrolyte compositions in rat. A J Physiol Biochem Pharmacol, 9 (3), 45-51. doi:10.5455/ajpbp.20190411102349



Turabian Style

Odukanmi, Olugbenga Adeola, Adeola Temitope Salami, Muideen Olayemi Isa, Samuel Babafemi Olaleye, and . 2019. Crude ethanolic extract and fractions of buchholzia coriacea modifies salivary secretion and electrolyte compositions in rat. American Journal of Physiology, Biochemistry and Pharmacology, 9 (3), 45-51. doi:10.5455/ajpbp.20190411102349



Chicago Style

Odukanmi, Olugbenga Adeola, Adeola Temitope Salami, Muideen Olayemi Isa, Samuel Babafemi Olaleye, and . "Crude ethanolic extract and fractions of buchholzia coriacea modifies salivary secretion and electrolyte compositions in rat." American Journal of Physiology, Biochemistry and Pharmacology 9 (2019), 45-51. doi:10.5455/ajpbp.20190411102349



MLA (The Modern Language Association) Style

Odukanmi, Olugbenga Adeola, Adeola Temitope Salami, Muideen Olayemi Isa, Samuel Babafemi Olaleye, and . "Crude ethanolic extract and fractions of buchholzia coriacea modifies salivary secretion and electrolyte compositions in rat." American Journal of Physiology, Biochemistry and Pharmacology 9.3 (2019), 45-51. Print. doi:10.5455/ajpbp.20190411102349



APA (American Psychological Association) Style

Odukanmi, O. A., Salami, A. T., Isa, M. O., Olaleye, S. B. & (2019) Crude ethanolic extract and fractions of buchholzia coriacea modifies salivary secretion and electrolyte compositions in rat. American Journal of Physiology, Biochemistry and Pharmacology, 9 (3), 45-51. doi:10.5455/ajpbp.20190411102349





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