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Serum Lipid Profile of Breast Cancer Patients in Kashmir

Showkat Ahmad Bhat, Manzoor R Mir, Sabhiya Majid, Ahmad Arif Reshi, Ishraq Husain, Tehseen Hassan, Hilal Ahmad.

Cited by (3)

Abstract
Malignancy of the breast is one of the commonest causes of death in women aged between 40-45 years. The aim of this study was to carry out a comparative study to investigate the effect of lipid profile, oestradiol (EST) and obesity on the risk of a woman developing breast cancer. In this study, 120 women including 60 breast cancer patients (25 to 80 years) were assessed for lipid profile, EST and Body Mass Index (BMI) and 60 controls with similar age range. There was a significant increase in Body Mass Index (BMI) (p = 0.011), Total Cholesterol (TC) (p<0.001), triglyceride (p = 0.026) and low density lipoprotein (LDL-cholesterol) (p = 0.001) of the breast cancer patients compared to the controls. With the exception of EST that decreased, the lipid profile generally (TG) increased with age in both subjects and controls with the subjects having a much higher value than the control taken in the study. There was also a significant positive correlation between BMI and TC (r2 = 0.022; p = 0.002) and also between BMI and LDL-cholesterol (r2 = 0.031; p = 0.0003). Apart from EST and LDL-cholesterol that were increased significantly only in the postmenopausal phase in comparison to the controls, BMI, TC and TG were increased in both pre-menopausal and post menopausal phases with HDL-cholesterol remaining unchanged. This study confirms the association between lipid profile, BMI and increased breast cancer risk.

Key words: Oestradiol, body mass index, cholesterol, triglyceride


 
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REFERENCES
1. Wernberg JA, Yap J, Murekeyisoni C, Mashtare T, Wilding GE. Multiple primary tumors in men with breast cancer review. J Surg Oncol. 2009;99:16-9. [DOI via Crossref]    [Pubmed]   
2. Goodwin PJ, Boyd NF, Hanna W, Hartwick W, Murray D, Qizilbash A, Redwood S, Hood N, DelGiudice ME, Sidlofsky S, McCready D, Wilkinson R, Mahoney L, Connelly P, Page DL. Elevated levels of plasma triglycerides are associated with histologically defined premenopausal breast cancer risk. Nutr Cancer. 1997;27(3):284-92. [DOI via Crossref]    [Pubmed]   
3. Li FP, Corkery J, Vawter G, Fine W, Sallan SE. Breast carcinoma after cancer therapy in childhood. Cancer. 1983;51(3):521-3. [DOI via Crossref]   
4. Polednak AP. Epidemiology of breast cancer in Connecticut women. Conn Med. 1999;63:7-16. [Pubmed]   
5. Armstrong B, Doll R. Environmental factors and cancer incidence and mortality in different countries, with special reference to dietary practices. Int J Cancer. 1975;15(4):617-31. [DOI via Crossref]   
6. McMichael AJ, Giles GG. Cancer descriptive epidemiological data. Cancer Res. 1988;48:751-756. [Pubmed]   
7. Bernstein L, Ross RK. Endogenous hormones and breast cancer risk. Epidemiol Rev 1993;15:48-65. [Pubmed]   
8. Moysich KB, Freudenheim JL, Baker JA. Ambrosone CB, Bowman ED, Apolipoprotein E genetic polymorphism, serum lipoproteins and breast cancer risk. Mol Carcinog. 2000;27:2-9. [DOI via Crossref]   
9. Sainsbury R. Treatment of early stage breast cancer and breast reconstruction A Companion to Specialist Surgical Practice. Breast and Endocrine Surgery 1999. Farndon JR (ed). London: Harcourt Brace and Company Ltd; 243–261.
10. Ballard-Barbash R. Anthropometry and breast cancer: Body size: A moving target. Cancer. 1994;74:1090-100. [DOI via Crossref]   
11. Qi XY, Zhang AY, Wu GL, Pang WZ. The association between breast cancer and diet and other factors. Asia Pac J Public Health. 1994;7(2):98-104. [DOI via Crossref]   
12. Kohlmeier L, Mendez M. Controversies surrounding diet and breast cancer. Proc Nutr Soc. 1997;56(1B):369-82. [DOI via Crossref]    [Pubmed]   
13. Törnberg SA, Holm LE, Carstensen JM. Breast cancer risk in relation to serum cholesterol, serum beta-lipoprotein, height, weight, and blood pressure. Acta Oncol. 1988;27(1):31-7. [DOI via Crossref]    [Pubmed]   
14. Abu-Bedair FA, El-Gamal BA, Ibrahim NA, El-Aaser AA. Serum lipids and tissue DNA content in Egyptian female breast cancer patients. Jpn J Clin Oncol. 2003;33(6):278-82. [DOI via Crossref]    [Pubmed]   
15. Bani IA, Williams CM, Boulter PS, Dickerson JW. Plasma lipids and prolactin in patients with breast cancer. Br J Cancer. 1986;54(3):439-46. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
16. Gaard M, Tretli S, Urdal P. Risk of breast cancer in relation to blood lipids: a prospective study of 31,209 Norwegian women. Cancer Causes Control. 1994;5(6):501-9. [DOI via Crossref]    [Pubmed]   
17. Kökoðlu E, Karaarslan I, Karaarslan HM, Baloðlu H. Alterations of serum lipids and lipoproteins in breast cancer. Cancer Lett. 1994;82(2):175-8. [DOI via Crossref]   
18. Buchwald H. Cholesterol inhibition, cancer, and chemotherapy. Lancet. 1992;339(8802):1154-6. [DOI via Crossref]   
19. Soma MR, Corsini A, Paoletti R. Cholesterol and mevalonic acid modulation in cell metabolism and multiplication. Toxicol Lett. 1992;64-65 Spec No:1-15. [DOI via Crossref]   
20. Goodwin PJ, Boyd NF, Hanna W, Hartwick W, Murray D, Qizilbash A, Redwood S, Hood N, DelGiudice ME, Sidlofsky S, McCready D, Wilkinson R, Mahoney L, Connelly P, Page DL. Elevated levels of plasma triglycerides are associated with histologically defined premenopausal breast cancer risk. Nutr Cancer. 1997;27(3):284-92. [DOI via Crossref]    [Pubmed]   
21. Kolonel LN, Nomura AM, Hinds MW, Hirohata T, Hankin JH, Lee J. Role of diet in cancer incidence in Hawaii. Cancer Res. 1983;43(5 Suppl):2397s-2402s. [Pubmed]   
22. Wu AH, Stram DO, C Pike M. RESPONSE: re: meta-analysis: dietary fat intake, serum estrogen levels, and the risk of breast cancer. J Natl Cancer Inst. 2000;92(1):78A-78. [DOI via Crossref]    [Pubmed]   
23. Skinner LG, England PC, Cottrell KM, Selwood RA. Proceedings: Serum oestradiol 17 beta in normal premenopausal women and in patients with benign and malignant breast disease. Br J Cancer. 1974;30(2):176-7. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
24. Hankinson SE, Willett WC, Manson JE, Colditz GA, Hunter DJ, Spiegelman D, Barbieri RL, Speizer FE. Plasma sex steroid hormone levels and risk of breast cancer in postmenopausal women. J Natl Cancer Inst. 1998;90(17):1292-9. [DOI via Crossref]    [Pubmed]   
25. Kabuto M, Akiba S, Stevens RG, Neriishi K, Land CE. A prospective study of estradiol and breast cancer in Japanese women. Cancer Epidemiol Biomarkers Prev. 2000;9(6):575-9. [Pubmed]   
26. De Waard F, Cornelis JP, Aoki K, Yoshida M. Breast cancer incidence according to weight and height in two cities of the Netherlands and in Aichi prefecture, Japan. Cancer. 1977;40(3):1269-75. [DOI via Crossref]   
27. Kumar V, Green S, Stack G, Berry M, Jin JR, Chambon P. Functional domains of the human estrogen receptor. Cell. 1987;51(6):941-51. [DOI via Crossref]   

This Article Cited By the following articles

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How to Cite this Article
Pubmed Style

Showkat Ahmad Bhat, Manzoor R Mir, Sabhiya Majid, Ahmad Arif Reshi, Ishraq Husain, Tehseen Hassan, Hilal Ahmad. Serum Lipid Profile of Breast Cancer Patients in Kashmir. A J Physiol Biochem Pharmacol. 2013; 2(1): 26-31. doi:10.5455/jib.20121125075314


Web Style

Showkat Ahmad Bhat, Manzoor R Mir, Sabhiya Majid, Ahmad Arif Reshi, Ishraq Husain, Tehseen Hassan, Hilal Ahmad. Serum Lipid Profile of Breast Cancer Patients in Kashmir. http://www.ajpbp.com/?mno=28029 [Access: December 16, 2018]. doi:10.5455/jib.20121125075314


AMA (American Medical Association) Style

Showkat Ahmad Bhat, Manzoor R Mir, Sabhiya Majid, Ahmad Arif Reshi, Ishraq Husain, Tehseen Hassan, Hilal Ahmad. Serum Lipid Profile of Breast Cancer Patients in Kashmir. A J Physiol Biochem Pharmacol. 2013; 2(1): 26-31. doi:10.5455/jib.20121125075314



Vancouver/ICMJE Style

Showkat Ahmad Bhat, Manzoor R Mir, Sabhiya Majid, Ahmad Arif Reshi, Ishraq Husain, Tehseen Hassan, Hilal Ahmad. Serum Lipid Profile of Breast Cancer Patients in Kashmir. A J Physiol Biochem Pharmacol. (2013), [cited December 16, 2018]; 2(1): 26-31. doi:10.5455/jib.20121125075314



Harvard Style

Showkat Ahmad Bhat, Manzoor R Mir, Sabhiya Majid, Ahmad Arif Reshi, Ishraq Husain, Tehseen Hassan, Hilal Ahmad (2013) Serum Lipid Profile of Breast Cancer Patients in Kashmir. A J Physiol Biochem Pharmacol, 2 (1), 26-31. doi:10.5455/jib.20121125075314



Turabian Style

Showkat Ahmad Bhat, Manzoor R Mir, Sabhiya Majid, Ahmad Arif Reshi, Ishraq Husain, Tehseen Hassan, Hilal Ahmad. 2013. Serum Lipid Profile of Breast Cancer Patients in Kashmir. American Journal of Physiology, Biochemistry and Pharmacology, 2 (1), 26-31. doi:10.5455/jib.20121125075314



Chicago Style

Showkat Ahmad Bhat, Manzoor R Mir, Sabhiya Majid, Ahmad Arif Reshi, Ishraq Husain, Tehseen Hassan, Hilal Ahmad. "Serum Lipid Profile of Breast Cancer Patients in Kashmir." American Journal of Physiology, Biochemistry and Pharmacology 2 (2013), 26-31. doi:10.5455/jib.20121125075314



MLA (The Modern Language Association) Style

Showkat Ahmad Bhat, Manzoor R Mir, Sabhiya Majid, Ahmad Arif Reshi, Ishraq Husain, Tehseen Hassan, Hilal Ahmad. "Serum Lipid Profile of Breast Cancer Patients in Kashmir." American Journal of Physiology, Biochemistry and Pharmacology 2.1 (2013), 26-31. Print. doi:10.5455/jib.20121125075314



APA (American Psychological Association) Style

Showkat Ahmad Bhat, Manzoor R Mir, Sabhiya Majid, Ahmad Arif Reshi, Ishraq Husain, Tehseen Hassan, Hilal Ahmad (2013) Serum Lipid Profile of Breast Cancer Patients in Kashmir. American Journal of Physiology, Biochemistry and Pharmacology, 2 (1), 26-31. doi:10.5455/jib.20121125075314





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