Prevalence of vitamin B12 deficiency in Helicobacter pylori infected patients in Jordan.

Saad Abed Aljalil Alfawaeir, Mohammad Basim Abuzaid

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J Investig Biochem. 2013; 2(1): 21-25

doi: 10.5455/jib.20121215061954

Prevalence of vitamin B12 deficiency in Helicobacter pylori infected patients in Jordan.

Saad Abed Aljalil Alfawaeir, Mohammad Basim Abuzaid.

Abstract
Objective: The purpose of this study is to assess the frequency of vitamin B 12 deficiency in patients with Helicobacter pylori (H. pylori) infection to determine whether low serum vitamin B12 levels correlate with serological evidence of H. pylori infection.
Background: An association between H. pylori infection and vitamin B12 deficiency has been recently reported.
Subjects: From 200 people blood was collected. For each subject serum vitamin B12, folic acid, complete blood count and H. pylori IgG antibodies were measured. 150 subjects have H. pylori infection and 50 subjects healthy control group. The following cases were excluded, history of H. pylori eradication or antacid take, liver disease, chronic alcoholism inflammatory bowel disease, previous gastrointestinal surgery and a vegetarian diet or multivitamin supplementation.
Results: Vitamin B12 deficiency was found in 87(58%) patients with seropositive H. pylori IgG antibodies (HP+) versus 9 (18%) patients with seronegative H. pylori IgG antibodies (HP).The mean±SD of serum vitamin B12 level in overall subjects (males and females) was 345.717± 215.214 and 271.254±35.234 (p < 0.01) respectively. The mean±SD of serum vitamin B12 level in H. pylori infected subjects was 295,574±71,482 versus 411,973±368,241in healthy group (p < 0.02). The mean±SD of serum vitamin B 12 level in overall H. pylori infected subjects with vitamin B12 deficiency (male and female) was 142±24.423 and 144.322±18.736 (p < 0.02) where it was 565.197±149.488 and 615.33±139.981 with normal serum vitamin B12 level in the same group.
Hemoglobin and hematocrit levels were significantly lower in H. pylori positive subjects, hemoglobin (g/dL) was 13.5±0.15 mean±SD versus 14.2±0.25, p < 0.05 and hematocrit (%) 40.1±0.35 versus 42 ±0.7 p < 0.05, Mean Corpuscular Volume (MCV) (Î¼m3) was 95±2% versus 85±2%.
Folic acid levels (normal range 4.6-12.7 ng/ml) were significantly lower in H. pylori seropositive subjects (5.65±0.2 versus 9.1±0.5 p < 0.05).
Conclusion: Collectible results suggest a causal relationship between H. pylori infection and vitamin B12 deficiency in Jordanians.

Key words: Key words: H. pylori, Vitamin B12, IgG antibodies.

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REFERENCES

1. Blaser M. The bacteria behind the ulcers. Sci Am 1996;274:92-7. [DOI via Crossref]

2. Logan R, Hirschl A. Epidemiology of helicobactor infection. Curr Opin Gastroenterol 1996;12:1-5. [DOI via Crossref]

3. Frenck R, Clemens J. Helicobacter in the developing world. Microbes Infect 2003;5:705-13. [DOI via Crossref]

4. Sarari AS, Farra MA, Hamodi Wessawi TA. Helicobacter pylori a causative agent of vitamin B12 deficiency. Jinfect Dev Ctries 2008;2:346-9.

5. Annibale B, Lahner E, Bordi C, Martino G, Caruana P, Grossi C. Role of helicobacter pylori infection in pernicious anaemia. Dig liver Dis 2000,32,756-62. [DOI via Crossref]

6. Fong TL, Doley CP, Dehesa M, Cohen H, Carmel R, Fitzgibbons PL. Helicobacter pylori infection in pernicious anemia: a prospective controlled study. Gastroenterology 199,100;328-32.

7. Oconnor HJ, Axon AT, Dixon MF. Campylobacter-like organisms unusual in type A (pernicious anaemia) gastritis. Lancet 1984;2;1091. [DOI via Crossref]

8. Nergini R, Zanella I, Savio A,Poiesi C, Verardi R, Ghielmi S. Serodiagnosis of Helicobacter pylori-associated gastritis with a monoclonal antibody competitive enzyme-linked immunsorbent assay. Scand J Gastroenterol 1992;27;559-65.

9. Dale A, Thomas JE, Darboe MK, Coward WA, Harding M, Weaver LT. Helicobacter pylori infection, gastric acid serection, and infant growth. J pediatr Gastroenterol Nutr 1998;26:393-7. [DOI via Crossref] [Pubmed]

10. Karnes WE, Samloff IM, Siurala M. Positive serum antibody and negative tissue staining for Helicobacter pylori in subjects with atrophic body gastritis Gastroenterology 1991;101:167-74. [Pubmed]

11. Varis O, Valle J, Suirala M. Is Helicobacter pylori involved in the pathogenesis of the gastritis characteristic of pernicious anemia? Scand J Gastroenterol 1993;28:705-8. [DOI via Crossref] [Pubmed]

12. GÃ¼mÃ¼rdÃ¼lÃ¼ Y, Serin E, Ozer B, KayaselÃ§uk F, Kul K, Pata C, GÃ¼Ã§lÃ¼ M, GÃ¼r G, BoyacioÃ°lu S. Predictors of vitamin B12 deficiency: age and Helicobactor load of antral mucosa. Turk. J. Gastroenterol, 2003;14(1):44-9. [Pubmed]

13. Tucker KL, Rich S, Rosenberg I, Jacques P, Dallal G, Wilson PW, Selhub J. Plasma vitamin B-12 concentration relate to intake source in the Framingham offspring study. Am J Clin Nutr 2000;71(2):514-22. [Pubmed]

14. Bikka RD, Shaikh MZ, Syed ZA, Tarachand D, Raj K, Thanwar D. Helicobactor pylori: A cause of vitamin B12 deficiency world. Applied Sciences Journal 2011;12(9):1378-1381.

15. Colon-Otero G, Menke D, Hook CC. A practical approach to the differential diagnosis and evaluation of the adult patient with macrocytic anemia. Med Clin North Am. 1992;76(3):581-97. [Pubmed]

16. Federici L, Henoun Loukili N, Zimmer J, Affenberger S, Maloisel F, AndrÃ¨s E. Update of clinical finding in cobalamin deficiency: personal data and review of the literature. Rev Med Interne. 2007;28(4):225-31. [DOI via Crossref] [Pubmed]

17. Fong TL, Dooley CP, Dehesa M, Cohen H, Carmel R, Fitzgibbons PL. Helicobacter pylori infection in pernicious anemia: a prospective controlled study. Gastroenterology 1991;100:328-32. [Pubmed]

18. Shuval-Sudai O, Granot E. An association between helicobacter pylori infection and serum vitamin B12 levels in healthy adults. J Clin Gastroenterol. 2003;36(2):130-3. [DOI via Crossref]

How to Cite this Article

Pubmed Style

Saad Abed Aljalil Alfawaeir, Mohammad Basim Abuzaid. Prevalence of vitamin B12 deficiency in Helicobacter pylori infected patients in Jordan.. A J Physiol Biochem Pharmacol. 2013; 2(1): 21-25. doi:10.5455/jib.20121215061954

Web Style

Saad Abed Aljalil Alfawaeir, Mohammad Basim Abuzaid. Prevalence of vitamin B12 deficiency in Helicobacter pylori infected patients in Jordan.. http://www.ajpbp.com/?mno=27435 [Access: February 21, 2019]. doi:10.5455/jib.20121215061954

AMA (American Medical Association) Style

Saad Abed Aljalil Alfawaeir, Mohammad Basim Abuzaid. Prevalence of vitamin B12 deficiency in Helicobacter pylori infected patients in Jordan.. A J Physiol Biochem Pharmacol. 2013; 2(1): 21-25. doi:10.5455/jib.20121215061954

Vancouver/ICMJE Style

Saad Abed Aljalil Alfawaeir, Mohammad Basim Abuzaid. Prevalence of vitamin B12 deficiency in Helicobacter pylori infected patients in Jordan.. A J Physiol Biochem Pharmacol. (2013), [cited February 21, 2019]; 2(1): 21-25. doi:10.5455/jib.20121215061954

Harvard Style

Saad Abed Aljalil Alfawaeir, Mohammad Basim Abuzaid (2013) Prevalence of vitamin B12 deficiency in Helicobacter pylori infected patients in Jordan.. A J Physiol Biochem Pharmacol, 2 (1), 21-25. doi:10.5455/jib.20121215061954

Turabian Style

Saad Abed Aljalil Alfawaeir, Mohammad Basim Abuzaid. 2013. Prevalence of vitamin B12 deficiency in Helicobacter pylori infected patients in Jordan.. American Journal of Physiology, Biochemistry and Pharmacology, 2 (1), 21-25. doi:10.5455/jib.20121215061954

Chicago Style

Saad Abed Aljalil Alfawaeir, Mohammad Basim Abuzaid. "Prevalence of vitamin B12 deficiency in Helicobacter pylori infected patients in Jordan.." American Journal of Physiology, Biochemistry and Pharmacology 2 (2013), 21-25. doi:10.5455/jib.20121215061954

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Saad Abed Aljalil Alfawaeir, Mohammad Basim Abuzaid (2013) Prevalence of vitamin B12 deficiency in Helicobacter pylori infected patients in Jordan.. American Journal of Physiology, Biochemistry and Pharmacology, 2 (1), 21-25. doi:10.5455/jib.20121215061954

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