Protective effects of selenium on some selective immunological and biochemical parameters in cadmium intoxicated rat

Abstract

E. El-Boshy Mohamed, F. Risha Engy, M. Abdel Hamid Fatma

Background and Objective: In this study, we investigate the protective effect of selenium (Se) against cadmium (Cd) intoxication in the rat by monitoring some selective cytokines (interleukin-1β [IL-1β], tumor necrosis factor-α [TNF-α], IL-6, IL10 and interferon gamma [IFN-γ]) and antioxidant enzymes (glutathione [GSH], catalase [CAT], superoxide dismutase [SOD], nitric oxide) and lipid peroxidation (malondialdehyde [MDA]). Material and Methods: The Cd was orally administrated at dose 20 and 40 mg/L in drinking water for 30 days. The Se orally administrated at a dose rate 0.1 mg/kg bw/day also for 30 days with Cd. Blood samples were collected from heart puncture at the end of experiment (30 days) and serum was separated for estimation the immunological parameters studies. Results: the Se improved elevation of serum IL1β, IL-6, TNF-α, IFN-γ and MDA as well as enhanced antioxidant enzymes activities GSH, CAT and SOD. Furthermore, Se ameliorate the Cd induce liver and kidney damage by improving hepatic and renal markers. Conclusions: We could be concluded that Se interaction with Cd extend our understanding of Se biological functions as a potential countermeasure against immunosuppressive as well as hepatic and renal oxidative damage induced by Cd in rats.