Myeloperoxidase, malondialdehyde and serum lipids in type 2 diabetes mellitus


Mohamedi Begum, Jeppu Ashok Kumar, Hilda Priya Dâ??Souza, Sushith Sushith, Mangalore Balakrishna Prathima, Reshma Shridhar, Shashikala Magadi Dasegowda, Manjula Anil, Suriyan Sasidharan Nair, Kavitha Ashok Kumar

Introduction: In diabetics, oxidative stress is increased in all stages of cardiovascular disease; from lipoprotein modification to plaque rupture. Oxidative stress increases the risk of development of cardiovascular complications. Atherogenic index of plasma (AIP) is related directly to the atherosclerotic risk. Oxidative stress markers have value in long-term cardiovascular risk prediction. In view of this, the present study was taken to compare and correlate the levels of oxidative stress markers and AIP in type 2 diabetic patients. Methods: A total of 140 individuals were included in the study. Of which 70 are type 2 diabetics and 70 are age and sex matched controls. Levels of serum myeloperoxidase (MPO), malandialdehyde (MDA), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and AIP is measured in these study population. Results and Conclusion: Statistically significant increase in body mass index (27.2 ±1.2 kg/m²), waist-hip ratio (1.02 ± 0.04), serum MPO (211.71 ± 2.24 μmol/min) and MDA (549 ± 45 nmole/100 ml), TC (274 ± 24 mg/dl), TG (189 ± 2.5 mg/dl), LDL-C (207 ± 45 mg/dl) and AIP (0.47 ± 0.02) was seen in type 2 diabetic patients when compared to controls. The levels of these parameters are higher in diabetic patients having diabetes ≥10 years and serum cholesterol ≥200 mg/dl. AIP was positively correlated with the levels of serum MPO, MDA, TC, TG, LDL-C and negatively correlated with serum HDL-C that was statistically significant. By measuring serum MPO, MDA, lipid profile and AIP helps in long-term cardiovascular risk assessment in patients with diabetes and by measuring these parameters help to detect these complications as early as possible and early interventions can be done to prevent future development of cardiovascular complications.