Alteration of antioxidant enzymes and oxidative stress in elderly patient

Abstract

Seema L. Jawalekar, Anil K. Bhutey, Aarti Karnik, Vasant T. Surve

Reactive oxygen spaces are common by-products of many oxidative biochemical and physiological processes. Therefore the present study was carried out to evaluate the total with hypertension, Diabetes with hypertension and cardiovascular diseases. Total 85 patients of both sexes were included in the study and further classified into 3 groups as hypertensive, Diabetes with hypertension and cerebrovascular disease/stroke. The 26 healthy subjects who were not on any kind of prescribed medication or dietary restrictions were included in the control group. Malondialdehyde is estimated as a marker of lipid peroxidation, levels were significantly increased in all groups than controls (p<0.001). Superoxide dismutase and glutathione reductase activities was significantly lower in all groups than control (p<0.001), Glutathione peroxidase levels were decreased in all groups except hypertension (p<0.001), nitric oxide level were decreased in all the groups except cerebrovascular disease / stroke when compared to the control. Significantly lower level of total antioxidant capacity and prominent scavenger of superoxide anion radicals suggests that failure of antioxidant defense mechanism against oxidative stress may be an important factor in the pathogenesis of cardiovascular diseases.